Binding of urokinase-type plasminogen activator–plasminogen activator inhibitor-1 complex to the endocytosis receptors α2-macroglobulin receptor/low-density lipoprotein receptor-related protein and very-low- density lipoprotein receptor involves basic residues in the inhibitor
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چکیده
Binding of urokinase-type plasminogen activator–plasminogen activator inhibitor-1 complex to the endocytosis receptors α2-macroglobulin receptor/low-density lipoprotein receptor-related protein and very-lowdensity lipoprotein receptor involves basic residues in the inhibitor Kees W. RODENBURG, Lars KJØLLER, Helle H. PETERSEN and Peter A. ANDREASEN Department of Molecular and Structural Biology, Aarhus University, 10 Gustav Wieds Vej, DK 8000 AI rhus C, Denmark
منابع مشابه
Inhibition of plasminogen activator inhibitor-1 binding to endocytosis receptors of the low-density-lipoprotein receptor family by a peptide isolated from a phage display library.
The functions of the serpin PAI-1 (plasminogen activator inhibitor-1) are based on molecular interactions with its target proteases uPA and tPA (urokinase-type and tissue-type plasminogen activator respectively), with vitronectin and with endocytosis receptors of the low-density-lipoprotein family. Understanding the significance of these interactions would be facilitated by the ability to block...
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